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KMID : 0928520090190030232
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Korean Journal of Lipidology
2009 Volume.19 No. 3 p.232 ~ p.240
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Female Patients with Angina Pectoris, Elevated Levels of Cholesteryl Ester Transfer Protein, ApoC-III, and Myeloperoxidase, and Impaired Antioxidant Ability in Serum
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Cho Kyung-Hyun
Shin Dong-Gu
Kim Jae-Ryong
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Abstract
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Angina pectoris (AP) is more prevalent in women in Westernized society. In order to investigate unique biomarkers of female patients with AP, we compared the plasma lipids and apolipoprotein profiles, as well as enzyme activities between female patients with AP (n=10) and age- and gender-matched controls (n=10). Although the AP group had similar levels of total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C), the AP group had a lower ratio of high-density lipoprotein (HDL)-C/TC. The C-reactive protein (CRP) and creatine kinase (CK)-MB levels were more elevated in the AP group, while the troponin level was in the normal range. The apoC-III level was elevated in the AP group, and the apoA-I level was lower than the control. Myeloperoxidase (MPO) and lipid peroxide (LPO) were increased in the AP group, while interleukin (IL-6) and lactate dehydrogenase (LDH) were not increased in the AP patients. Serum cholesteryl ester transfer protein activity was enhanced in the AP group, while lecithin:cholesterol acyltransferase activity was much lower than the control group. In conclusion, the HDL-C/TC ratio may be a good indicator for coronary heart disease, including AP. The plasma levels of MPO, apoC-III, and CETP were elevated in the AP group with a decrease in LCAT and apoA-I.
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KEYWORD
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